Yesterday I mentioned the severity of MS08-006. Last night, HD Moore posted an analysis of this patch.
This is a server issue, and is only enabled by the use of certain coding practices that are not bad in and of themselves. Considering most admins have no idea what code is going on their systems, either from internal developers or third-party web products, this patch should still be critical for servers. I assume a purposely vulnerable and dangerous asp file will be released in the next few weeks that I can copy, put on a server, and auto-pwn it in some way (shovel a shell over asp?).